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srfAB [2017-05-10 18:05:36]
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srfAB [2017-05-10 18:05:36]

surfactin synthetase / competence
Locus
BSU03490
Isoelectric point
4.90
Molecular weight
400.86 kDa
Protein length
3587 aa Sequence Blast
Gene length
10761 bp Sequence Blast
Function
antibiotic synthesis
Product
surfactin synthetase / competence
Essential
no
Synonyms
comL

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
387,744 → 398,495

The protein

Protein family

  • ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)
  • Paralogous protein(s)

  • complete length: PpsC, PpsD, SrfAA, SrfAB
  • partial match (more than 1,000 amino acids): DhbF, PksJ, PksN, PpsA, PpsB, PpsE, SrfAC
  • Modification

  • phosphorylation on Ser-999 AND Ser-2045 PubMed
  • phosphorylated on Arg-1378 PubMed
  • Structure

  • 2VSQ (termination module of SrfAC, 39% identity) PubMed
  • Localization

  • membrane PubMed
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • PhoP: activation, PubMed, in PhoP regulon
  • CodY: repression, PubMed, in CodY regulon
  • ComA: activation, PubMed, in ComA regulon
  • PerR: activation, PubMed, in PerR regulon
  • Spx: repression, PubMed, in Spx regulon
  • Abh: repression, PubMed, in Abh regulon
  • Regulation

  • expressed at high cell density (ComA) PubMed
  • Additional information

  • A ncRNA is predicted between 'hxlR' and 'srfAA' PubMed
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    References

    Reviews

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    Original publications

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